Expression data of mRNA/LncRNA from megakaryocytes in MLL-AF9 AML mouse versus healthy control bone marrow

Thrombocytopenia is a major and fatal complication for AML, while what happened to megakaryopoiesis and thrombopoiesis in AML remains unknown. Megakaryocytes have been recognized as essential HSC niche cells for their function to maintain HSC quiescence and support HSC regeneration. Megakaryocytes are robustly affected in AML bone marrow, while the alterations of their platelet-releasing and HSC supportive function are incompletely understood. Megakaryocytes (SSChigh CD41high, DNA content ≧ 8N) were isolated from MLL-AF9 induced AML mice and healthy control mice bone marrow by flow cytometry.