Summary of principles of tissue specificity.

Changes of expression and hubness for transcription factors and genes with tissue-specific functions. All reported results were statistically significant by both a parametric (T) test and a non-parametric (bootstrap) test. As an additional confirmation, because gene sets in different tissues may have different properties, we also examined each gene set individually. We include the bootstrap probabilities in parentheses below, along with the proportion of gene sets/tissues for which the conclusion held true. To conduct the bootstrap comparisons, we compared values of expression and hubness for tsTFs, gTFs, and tsFXNGs to those for randomly selected set of genes in each tissue and repeated for 1000 iterates.
Summary of principles of tissue specificity.