Intramolecular Asymmetric Heck Reactions: Evidence for Dynamic Kinetic Resolution Effects

Enantioselectivity of the cyclization of 1 varies at different stages in the reaction. X-ray crystallography has shown that 1 exists as enantiomerically
pure (M) and (P) chiral helical structures defined by the relative orientations of the arene, amide, and alkene. The relative rates of interconversion
of the rotamers of 1 have been established, leading to mechanistic proposals to account for the variation of ee based on kinetic resolution
effects.