Association of clinical features with overall survival (OS).

The columns are: variable name; Spearman correlation between variable and OS for uncensored patients; p-value of the Spearman correlation; Cox proportional hazard ratio (HR) for all patients between individual clinical features and OS; p-values of the HR (Wald test); HR for all patients using all clinical variables and OS; p-value (Wald test) for the HR using all clinical features. The clinical covariates in this table include age at diagnosis (continuous), tumor size in centimeters (continuous), histological grade (ordinal) and whether the patient received hormone therapy (treated vs. untreated), radiotherapy (treated vs. untreated), or chemotherapy (treated vs. untreated). In addition, there are clinical covariates for common breast cancer subtype markers including HER2 status (positive vs. negative), ER status (positive vs. negative) and PR status (positive vs. negative) individually, as well as joint ER and PR status (ERPR) and triple negative status (tripleNegative) when a patient is negative for ER, PR, and HER. Histological types are: medullary carcinomas, mixed invasive, infiltrating ductal carcinomas (IDC), mucinous carcinomas, and infiltrating lobular carcinomas. Histology is treated as a categorical level variable, with ILC as the baseline. The multivariate Cox model also includes site as a categorical level variable to adjust for inclusion site (not reported). In the multivariate analyses ER status/endocrine treatment and chemotherapy/node status will be confounded. The table is sorted on the p-values of the multivariate analysis.