Impact of urine from cranberry-treated volunteers on global gene expression of uropathogenic Escherichia coli

Growth in urine of cranberry extract-treated volunteers did not markedly affect the transcirptome of UPEC strain UTI89. Expression of bacterial adhesin determinants (P fimbriae, S fimbrae, curli) was not markedly changed upon growth in the urine samples, while a slight, but non-significant upregulation of type 1 fimbriae was observed. Overall design: Examination of the transcriptome of uropathogenic E. coli after 2 h incubation in urine of cranberry extract-treated human volunteers (one replicate) in comparison to 2 h incubation in urine of the same volunteers before cranberry treatment (one replicate).