WP4658 - Small cell lung cancer - Homo sapiens
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资源简介：
Small cell lung carcinoma (SCLC) is a highly malignant cancer of the lung.
Genes altered in small cell lung carcinoma:
* TP53 is mutated in 70-90% of SCLCs.
* RB1 is inactivated in most SCLCs.
* PTEN is mutated in 2-10% of SCLCs.
* MYC amplifications and amplification of MYC family members is found in 30% of SCLCs.
* FHIT protein expression is lost due to Loss of heterozygocity (LOH) on chromosome arm 3p found in more than 80% of SCLCs.
This description was adapted from [Wikipedia](https://en.wikipedia.org/wiki/Small-cell_carcinoma).
Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.
创建时间：
2025-04-17
