Circadian rhythms are controlled by transcriptional feedback loops of clock genes and proteins. The stability of clock proteins is regulated by post-translational modification, such as phosphorylation

NIAID Data Ecosystem40

STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H7 PROTEIN KINASE INHIBITOR 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE

蛋白激酶抑制剂

药物靶点相互作用

STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H7 PROTEIN KINASE INHIBITOR 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE Descriptor: 1-(5-ISOQUINOLINESULFONYL)-2-M

Protein Data Bank Japan2024-10-23 更新50

Primary hits identified in a PKD1 inhibitor screen of a targeted library.

蛋白激酶抑制剂

药物发现早期评估

A targeted protein kinase inhibitor library of 80 compounds was screened for PKD1 inhibitory activity at 1 µM using an in vitro radiometric PKD1 kinase assay. Sixteen compounds were selected as primar

NIAID Data Ecosystem50