BK large conductance calcium-activated K+ channels (KCa1.1) are expressed widely across many tissues, contributing to systemic regulation of cardiovascular, neurological, and other specialized physiol
Italics mark the TALEN-discrimination sequence. The letter in italic and bold (C) indicates the nucleotide that should be substituted by T. The letter in bold (T) indicates the nucleotide substitution
We designed a series of cytosine base editors by tethering cytosine or adenosine deaminases to different stem/loops of Cas9 sgRNA (sgBEs). Deep sequencing was performed to investigate the editing feat
