Circadian Epigenomic Control of Skeletal Muscle Fuel Metabolism by HDAC3

We address the function of HDAC3 in skeletal muscle metabolism We performed HDAC3 ChIP-seq, RNA-seq, and GRO-seq in mouse muscles at different times of the day and compared between WT and HDAC3-depleted muscles.本研究旨在探究组蛋白去乙酰化酶3（HDAC3）在骨骼肌代谢中的功能。我们于每日不同时段对小鼠肌肉开展HDAC3染色质免疫共沉淀测序（HDAC3 ChIP-seq）、转录组测序（RNA-seq）以及全局运行测序（GRO-seq）实验，并对比分析野生型（WT）与HDAC3缺失的小鼠肌肉样本。