Gene expression profile of U2-OS control and NSD3 knockdown cells. Gene expression profile of U2-OS control and NSD3 knockdown cells
收藏NIAID Data Ecosystem2026-03-10 收录
下载链接：
https://www.ncbi.nlm.nih.gov/bioproject/PRJNA484629
下载链接
链接失效反馈官方服务：
资源简介：
Osteosarcomas (OS) have highly chaotic genomes, yet their cancer drivers are poorly defined. Leveraging cross-species OS genomics we identify the frequent amplification of NSD3, a histone lysine methyltransferase and expose the NSD3-ARID3A axis as a core pathway in osteosarcomagenesis. Loss- and gain-of-function studies with CRISPR-Cas9 and lentivirus systems establish the causal role of NSD3 in OS tumor growth and spontaneous metastasis. Overall design: Expression microarrays are performed to study the mechanism of NSD3 on promoting OS progression
创建时间：
2018-08-05
