PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)
收藏reactome.org2025-01-21 收录
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The mitochondrial endopeptidase PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) yielding SMDT1 (Konig et al. 2016). Mature SMDT1 is assembled into the MCU complex where it serves to bridge the MCU pore and the MCU regulators MICU1 and MICU2 (or MICU3 in neurons).
线粒体内肽酶PMPCA:PMPCB切割前SMDT1(前EMRE)的转运肽,从而产生SMDT1(Konig等人,2016年)。成熟的SMDT1组装成MCU复合体,在其中充当连接MCU通道与MCU调控因子MICU1和MICU2(或神经元中的MICU3)的桥梁作用。
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