Tumor-stromal communication within the microenvironment contributes to initiation of metastasis and may present a therapeutic opportunity. Using serial single cell RNA-sequencing in an orthotopic mous

NIAID Data Ecosystem40

Nuclear translocation of Cx43 promotes CRC progression by CAF via activating Ã-catenin through TGF-Ã and phosphorylation

结直肠癌分子机制

肿瘤微环境信号

The tumor microenvironment (TME) significantly influences intercellular communication, wherein a lot of secreted factors are known to activate both tumor cells and fibroblasts. Connexin43 (Cx43), a cr

NIAID Data Ecosystem20

DataSheet_2_HBx Mediated Increase of DDX17 Contributes to HBV-Related Hepatocellular Carcinoma Tumorigenesis.xlsx

肝癌研究

病毒致癌机制

HBV is strongly associated with HCC development and DEAD-box RNA helicase 17 (DDX17) is a very important member of the DEAD box family that plays key roles in HCC development by promoting cancer metas

NIAID Data Ecosystem40

Data_Sheet_1_IL-4/IL-13 Stimulated Macrophages Enhance Breast Cancer Invasion Via Rho-GTPase Regulation of Synergistic VEGF/CCL-18 Signaling.pdf

癌症转移机制

肿瘤微环境信号

Tumor associated macrophages (TAMs) are increasingly recognized as major contributors to the metastatic progression of breast cancer and enriched levels of TAMs often correlate with poor prognosis. De

NIAID Data Ecosystem20

HPV16 E7 expression effect on expression profile mediated by tumor necrosis factor

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