Bidirectional Synthesis of the Central Amino Acid of Chloptosin
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https://figshare.com/articles/dataset/Bidirectional_Synthesis_of_the_Central_Amino_Acid_of_Chloptosin/3054217
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资源简介：
An efficient total synthesis of (2S,2‘S,3aR,3‘aR,8aR,8‘aR)-6,6‘-dichloro-3a,3‘a-dihydroxy-1,1‘,2,2‘,3,3a,3‘,3‘a,8,8a,8‘,8‘a-dodecahydro-5,5‘-bipyrrolo[2,3-b]indole-2,2‘-dicarboxylic acid, the central amino acid component of chloptosin (1), is described. Starting from m-chloronitrobenzene,
this C2-symmetrical amino acid was synthesized by using a 14-step route, in which a Zinin benzidine rearrangement, intramolecular Heck
reaction, and selenocyclization and oxidative deselenation served as key steps. The absolute stereochemistry of the target was confirmed by
X-ray single-crystal studies on a key intermediate (17).
创建时间：
2016-02-29
