A splicing-dependent transcriptional checkpoint associated with pre-spliceosome formation

There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown已有充分证据表明，真核生物（eukaryotes）中的剪接（splicing）与转录（transcription）之间存在功能性相互作用，但这些过程如何以及为何实现偶联仍未明确。