Glucocorticoid (GC)- sensitive cells are killed by receptor (GR)-filling concentrations of GC for a sufficient time. We used 2 closely related clones ( sensitive, 1 resistant) from the CEM line of ALL

NIAID Data Ecosystem50

Nitric Oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance. Homo sapiens

靶向治疗机制

白血病细胞

JS-K, a NO donor which capable to induce cancer apopotosis, it's killing mechanism was investigated in this study. We found out that JS-K induce apopotosis via deregulating the GSH/GSSG redox couple.

NIAID Data Ecosystem70

CD137 Is Induced by the CD40 Signal on Chronic Lymphocytic Leukemia B Cells and Transduces the Survival Signal via NF-κB Activation

免疫信号通路

白血病细胞

CD137 is a member of the tumor necrosis factor receptor family that is expressed on activated T cells. This molecule provides a co-stimulatory signal that enhances the survival, and differentiation of

NIAID Data Ecosystem60