mRNA and microRNA Transcriptional Profiling of Gestation Day 21 Female Rat Liver and Placenta following Gestation Day 6 - 20 Ketoconazole Exposure

We report the RNAseq-based mRNA and microRNA transcriptome profiles of gestation day 21 female rat liver and placenta following oral ketoconazole exposure from gestation day 6 to 20. A treatment-related change in mRNA and microRNA levels was observed in both liver and placenta.本研究报道了妊娠第6天至第20天经口给予酮康唑暴露后，妊娠第21天雌性大鼠肝脏与胎盘的基于RNA测序（RNAseq）的mRNA及微小RNA（microRNA）转录组表达谱。在肝脏及胎盘组织中均观察到与该处理因素相关的mRNA及微小RNA表达水平变化。