Poly(A)-tail profiling reveals an embryonic switch in translational control

Poly(A) tails enhance the stability and translation of most eukaryotic messenger RNAs, but difficulties in globally measuring poly(A)-tail lengths have impeded greater understanding of poly(A)-tail function多聚腺苷酸尾（Poly(A) tails）可增强绝大多数真核生物信使RNA（messenger RNA，mRNA）的稳定性与翻译效率，但由于全局定量检测多聚腺苷酸尾长度存在技术瓶颈，学界对其功能的深入理解仍受到显著阻碍。