Pharmacologic C5aR1 antagonism in the Arctic mouse model of Alzheimer’s disease modifies microglial polarization and astrocyte signaling
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE240950
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SC and SN RNA-seq reveal that pharmacologic inhibition of C5aR1 both suppresses disease enhancing processes and promotes disease mitigating pathways in an AD mouse model. The Arctic model of Alzheimer's disease and wildtype mice were treated with a C5aR1 antagonist (PMX205) or not for 12 weeks. Hippocampi were dissect and processed for single cell and single nucleus RNA-sequencing
创建时间：
2024-08-29
