X-ray structure of the drug binding domain of AlbA in complex with the KMR-14-14 compound of the pyrrolobenzodiazepines class

X-ray structure of the drug binding domain of AlbA in complex with the KMR-14-14 compound of the pyrrolobenzodiazepines class Descriptor: (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, Albicidin resistance protein, ethyl 4-[[5-[[4-[4-[[(6~{a}~{S})-2-methoxy-11-oxidanylidene-6~{a},7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]butanoylamino]-1-methyl-pyrrol-2-yl]carbonylamino]-1-benzothiophen-2-yl]carbonylamino]-1-methyl-imidazole-2-carboxylate, ... Authors: Di Palma, M, Surani, Y.M, Rahman, K.M, Steiner, R.A. Deposit date: 2024-01-01 Release date: 2025-01-15 Last modified: 2026-07-01 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Convergent evolution of antibiotic resistance mechanisms between pyrrolobenzodiazepines and albicidin in multidrug resistant Klebsiella pneumoniae. NPJ Antimicrob Resist, 3, 2025