<strong>Immunomodulatory Effects of Pirdot Leaf Ethanol Extract (</strong><em><strong>Saurauia vulcani</strong></em><strong>. Korth ) on Hepatic CD4+ T cell Profile and Serum IL 2 Levels in Wistar Strain Mice Induced </strong><em><strong>Salmonella typhimurium</strong></em>

<strong>Introductions:</strong> Elements of the immune system that contributes to salmonella infection is CD4+ and IL2 T cells. One of the herbs that play a role in immunity is pirdot leaves (Saurauia vulcani Korth) which contains flavonoids that play a role in inflammation. <strong>Aims:</strong> the study to investigated Immunomodulatory Effects of Pirdot Leaf Ethanol Extract (<em>Saurauia vulcani</em>. Korth ) on Hepatic CD4+ T cell Profile and Serum IL 2 Levels in Wistar Strain Mice Induced <em>Salmonella typhimurium.</em> <strong>Methods:</strong> experimental research post-test design only control group. Male wistar rats are divided into 4 groups: I. Normal (KO), II. Negative (Kneg), III. Imboost 22.5 mg/kgBB (KPos), IV. Ethanol extract of pirdot leaves 500mg/kgBB(P). Groups II-IV received s injections. thypimurium on the 4th day. Blood is obtained from the heart and the liver at the conclusion of the killed animal in order to assess the liver's CD4 + T cells, histology, and IL 2 levels. <strong>Results:</strong> The Kruskal-Wallis test and Whitney Man Test were used to examine the data. The results were the highest levels of IL 2 in pirdot (2.23 ±0.18)ng/ml,followed by KPO (1.86 ±0.33)ng/ml,K0 (1.71±0.40)ng/ml, and the lowest at KNeg (1.64±0.28)ng/ml.The average value of histopathological structure score in Kruskal-Wallis test showed significant differences in necrosis hydropic degeneration, inflammation, granuloma, porta triad damage (p&lt;0.05). Meanwhile the comparison of CD4 + T cell IRS score results there were significant differences in all groups p=0.004. <strong>Conclusion:</strong> Pirdot leaf ethanol extract dosage of 500mg/kgBB improved CD4 + T cell IRS scores and serum IL 2 levels compared to other groups.