In vitro absorption-distribution-metabolism-excretion (ADME) properties of Compounds 1, 10, 12, 13 and control compounds.
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Aqueous solubility, permeation and retention in artificial membrane, metabolic stability against mouse liver microsomes (t1/2 or half-life), and intrinsic clearance (Clint) were determined as described in Materials and Methods. Values were also determined for albendazole, carbamazepine, ranitidine, and verapamil as control drugs. ND indicates not done.In vitro absorption-distribution-metabolism-excretion (ADME) properties of Compounds 1, 10, 12, 13 and control compounds.
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2015-12-03
