nsp13 binds DDX5

This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.<br><br>nsp13, the helicase of the human SARS coronavirus 1 (SARS-CoV-1) binds to DDX5, a host protein implicated in transcription, pre-mRNA processing, RNA degradation, RNA export, ribosome assembly and translation. DDX5 knockdown inhibits viral replication (Chen et al. 2009).

本COVID-19事件系通过结合从SARS-CoV-1数据中提取的计算推理（详见https://reactome.org/documentation/inferred-events）以及手动编纂而成，具体编纂过程详述于SARS-CoV-2感染途径的总结中。<br><br>nsp13，即人SARS冠状病毒1（SARS-CoV-1）的解旋酶，与DDX5（一种参与转录、前mRNA处理、RNA降解、RNA输出、核糖体组装和翻译的宿主蛋白）结合。DDX5的敲低可抑制病毒复制（Chen等人，2009年）。