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Organocatalytic Direct Asymmetric Vinylogous Michael Reaction of an α,β-Unsaturated γ-Butyrolactam with Enones

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Figshare2016-02-23 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Organocatalytic_Direct_Asymmetric_Vinylogous_Michael_Reaction_of_an_Unsaturated_Butyrolactam_with_Enones/2686492
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An organocatalytic asymmetric direct vinylogous Michael addition of α,β-unsaturated γ-butyrolactam to enones has been achieved with a simple bifunctional thiourea-tertiary amine catalyst, affording the γ-substituted butyrolactam products with high diastereo- and enantioselectivity (up to >40:1 dr and 94−99% ee).
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2016-02-23
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