Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE224358
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资源简介：
Two RNA binding proteins, UPF1 and LIN28A, have well-known functions in posttranscriptional regulations and stem cell differentiation. Most studies on UPF1 and LIN28A have focused on the molecular mechanism in differentiated cells and stem cell differentiation, respectively. We revealed that LIN28A directly interacts with UPF1, which happens before UPF1 forms a complex with UPF2, thereby resulting in the reduction of UPF1 phosphorylation and inhibition of nonsense-mediated mRNA decay (NMD). Our studies reveal that cell fate is determined by transcriptome regulation through UPF1-LIN28A interaction in hPSCs. Examination of the influence of UPF1-LIN28A interaction in hPSCs and differentiated cells
创建时间：
2024-01-16
