Neuronal networks models datasets

Simple Single-Cell Networks (6 files)TCRc.net.nml - Single core-type Thalamocortical Relay cellTCRil.net.nml - Single intralaminar TCR cellTCRm.net.nml - Single matrix-type TCR cellnRTc.net.nml, nRTil.net.nml, nRTm.net.nml - Single nRT cells of different subtypesThese contain:Single cell populations (size=1)Multiple stimulus types (pulse, sine, ramp, voltage clamp)Basic network structure for single-cell electrophysiology experimentsIntermediate Thalamocortical Networks (4 files)TC2PT.net.nml (68MB) - Thalamus to Pyramidal Tract pathwayTC2CT.net.nml (8.5MB) - Thalamus to Corticothalamic pathwayTC2IT2PTCT.net.nml (41MB) - Complex thalamo-cortical-thalamic loop with IT interneuronsTC2IT4_IT2CT.net.nml (38MB) - Layer 4-specific thalamocortical processingThese contain:Multiple cell populations from different cortical layers (L23, L4, L5, L6)All major cell types: PT, IT, CT neurons with their specific morphological variantsThalamic components: TCR and nRT cells of all subtypes (core, matrix, intralaminar)Comprehensive synaptic connectivity with realistic synapse models (AMPA, NMDA, GABAa, GABAb, gap junctions)Layer-specific input patterns with individual pulse generators for each cell typeLarge-Scale Cortical Networks (7 files)M1_max_plus.net.nml (235MB) - Primary motor cortex maximal modelM2_max_plus.net.nml (227MB) - Secondary motor cortexM2M1S1_max_plus.net.nml (963MB) - Multi-region motor-sensory integrationM2aM1aS1a_max_plus.net.nml (377MB) - Alternative multi-region configurationM1a_max_plus.net.nml (66MB) - Alternative M1 configurationS1bM1bM2b_max_plus.net.nml (423MB) - Another multi-region variantmax_CTC_plus.net.nml (43MB) - Maximal corticothalamic circuitKey Structural Features1. Cell Population Diversity:Cortical cells: All major types (PT, IT, CT) across all layers (L1-L6)Thalamic cells: TCR and nRT cells with core/matrix/intralaminar subtypesMorphological variants: Each cell type includes multiple morphological instances with unique identifiers2. Synaptic Architecture:Excitatory synapses: AMPA, NMDA, and combined AMPA_NMDAInhibitory synapses: GABAa, GABAb, and combined GABAElectrical coupling: Gap junctions for realistic connectivityRealistic parameters: Conductance values, time constants, and reversal potentials based on experimental data3. Input Configuration:Individual stimulation: Each cell receives its own excitatory and inhibitory pulse generatorsBalanced inputs: Excitatory and inhibitory amplitudes tuned for each cell typeTemporal control: 20-second duration inputs for sustained network activity4. Network Scale Progression:Single cells → Local circuits → Layer-specific pathways → Multi-region integrationFile sizes range from 1.5KB (single cells) to 963MB (full multi-region networks)Cell counts increase from 1 to thousands of neurons across multiple brain regionsThis hierarchical organization from single-cell biophysics to large-scale thalamocortical network interactions,