Crystal Growth, Single Crystal Structure, and Biological Activity of Thiazolo-Pyridine Dicarboxylic Acid Derivatives
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https://figshare.com/articles/dataset/Crystal_Growth_Single_Crystal_Structure_and_Biological_Activity_of_Thiazolo-Pyridine_Dicarboxylic_Acid_Derivatives/13132832
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资源简介：
Four
novel TPDCA derivatives were prepared via a supersaturation
method combining TPDCA with water, N-methyl-2-pyrrolidone
(NMP), Na(PO2H2), and ammonia solution: 2(C9H7NO5S)H2O (1), (C9H7NO5S)C5H9NO (2), (C9H7NO5S)Na(PO2H2) (3), and (C9H5NO5S)(NH4)2(H2O) (4). Their crystal structures were determined by
single-crystal X-ray diffraction. Compounds (1) and (2) crystallize in the monoclinic space groups P21 and P21/c, respectively, whereas compounds (3) and (4) crystallize in the triclinic space group P1̅.
Weak and moderate hydrogen bonds were detected in the four compounds.
In the biological tests, (1) and (3) exhibited
significant antibacterial activity against Escherichia
coli and Staphylococcus aureus; in addition, (1) was cytotoxic against leukemia HL-60
cells with the IC50 value of 158.5 ± 12.5 μM.
创建时间：
2020-10-22
