Synthetic lethal siRNA screen using a kinome library containing 939 druggable genes in the TN-IBC cell line SUM149PT, in combination with EPA treatment. Overall design: To identify a targetable candid

NIAID Data Ecosystem40

Synthetic lethality/slow growth with acs2-Ts8. Saccharomyces cerevisiae

基因互作分析

合成致死性筛选

Obtain synthetic lethality/slow growth gene interactors of acs2-Ts8 Keywords: gene mutation Overall design: The DNAs from one control single YKO population and one experimental double YKO acs2-Ts8 wer

NIAID Data Ecosystem30

Systematic kinase inhibitor profiling identifies CDK9 as a synthetic lethal target in NUT midline carcinoma

癌症靶向治疗

合成致死性筛选

Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors we

NIAID Data Ecosystem60

smc3 acetyl mimics and elg1 deletion can not bypass ctf7-203 ctf18 synthetic lethality.

合成致死性筛选

遗传相互作用

Cells harboring ctf7-203 mutation along with smc3K113Q acetyl mimic and elg1 deletion were crossed to ctf18 knockout cells carrying smc3K113Q acetyl mimic. Diploids were sporulated, dissected and tetr

NIAID Data Ecosystem40

Kinome-wide shRNA screen for synthetic lethality in patient-derived FANCA-deficient fibroblasts.

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