Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury

Here we demonstrate that the neurovasculature exhibits a unique transcriptional signature following inflammatory insults, and pharmacological inhibition of monoacylglycerol lipase using a newly characterized inhibitor, rescues the transcriptional profile of brain vasculature, and restores its functional homeostasis. Overall design: RNAseq of neurovasculature isolated from mice treated with lipopolysaccharides or PBS in the presence and absence of an inhibitor of monoacylglycerol lipase