High-Throughput Screening for Myelination Promoting Compounds Using Human Stem Cell-derived Oligodendrocyte Progenitor Cells Identifies Novel Targets. High-Throughput Screening for Myelination Promoting Compounds Using Human Stem Cell-derived Oligodendrocyte Progenitor Cells Identifies Novel Targets

High-Throughput Screening for Myelination Promoting Compounds Using Human Stem Cell-derived Oligodendrocyte Progenitor Cells Identifies Novel Targets Overall design: The reporter hESCs were differentiated to OPCs by following the protocol described above. On day 30 of differentiation, neurospheres were plated on a 6-well culture dish to facilitate OPC migration from the plated spheres. 3 wells of day 80 differentiating cultures were treated DMSO as control and two wells each were treated with different small molecules for 10 days