Gene expression profile at single cell level of whole embryonic (E16.5) and early postnatal (P3) mouse liver

To study molecular differences betweeem wild-type and cholestatic livers of a Jag1Ndr mouse model of Alagille syndrome (Andersson, Chivukula, Hankeova, et al. Gastroenterology, 2018;154(4):1080-1095), we used single cell RNA sequencing (scRNA-seq) of prenatal (E16.5) and early postnatal (P3) livers.为探究阿拉基尔综合征（Alagille syndrome）的Jag1Ndr小鼠模型的野生型（wild-type）与胆汁淤积性肝脏之间的分子差异（Andersson、Chivukula、Hankeova等，《胃肠病学》，2018；154(4)：1080-1095），本研究对胚胎期（E16.5）及出生早期（P3）的肝脏样本开展了单细胞RNA测序（single cell RNA sequencing，scRNA-seq）。