Engineered exosomes reprogram Gli1+ cells in vivo to prevent calcification of vascular grafts and autologous pathological vessels

Engineered exosomes reprogrammed Gli1+ cells to promote SMC reconstruction and inhibit calcification in TEVBs and autologous pathological vessels.工程化外泌体（Engineered exosomes）可重编程Gli1阳性细胞（Gli1+ cells），进而在组织工程血管旁路（TEVBs）与自体病变血管中促进平滑肌细胞（SMC）重构并抑制钙化。