Crystal structure of the catalytic domain of human PARP1 in complex with inhibitor EB-47
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Crystal structure of the catalytic domain of human PARP1 in complex with inhibitor EB-47 Descriptor: 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide, Poly [ADP-ribose] polymerase 1, SULFATE ION Authors: Schimpl, M, Ogden, T.E.H, Yang, J.-C, Easton, L.E, Underwood, E, Rawlins, P.B, Johannes, J.W, Embrey, K.J, Neuhaus, D. Deposit date: 2020-09-04 Release date: 2021-01-13 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition. Nucleic Acids Res., 49, 2021
创建时间：
2020-09-04
