Combination with ERR gamma agonist and mechanical stretching enhances maturation of 3D cardiac tissue and manifests the hypertrophic cardiomyopathy phenotype

Here, we established a method for maturating engineered cardiac tissue and creating manifested its HCM model using human induced prulipotent stem cells dericed cardiomyocytes and its isogenic cells. RNA-seq data for ECTs treated with static condition under DMSO treatment, static condition under T112 treatment, mechanical stimulation under DMSO tratment and mechanical stimulation under T112 to assess maturation. And RNA-seq data for ECTs treated mechanical stimulation under T112 harbouring WT, MYH7 R719Q or MYBPC3 G115*.