PDE12 expression data from diabetes patients and controls
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https://datadryad.org/dataset/doi:10.5061/dryad.d7wm37q4b
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资源简介：
Type 1 diabetes (T1D) incidence is increased after COVID-19 infection in
children under 18 years of age. Interferon-α-activated oligoadenylate
synthetase and downstream RNAseL activation degrade pathogen RNA, but can
also damage host RNA when RNAseL activity is poorly regulated. One such
regulator is PDE12 which degrades 2′-5′ oligoadenylate units, thereby
decreasing RNAseL activity. We analyzed PDE12 expression in islets from
non-diabetic donors, individuals with newly (median disease duration 35
days) and recently (5 years) diagnosed T1D, and individuals with type 2
diabetes (T2D). We also analyzed PDE12 single-nucleotide polymorphisms
(SNPs) relative to T1D incidence. PDE12 expression was decreased in
individuals with recently diagnosed T1D, in three of five individuals with
newly diagnosed T1D, but not in individuals with T2D. Two rare PDE12 SNPs
were found to have odds ratios of 1.80 and 1.74 for T1D development. We
discuss whether decreased PDE12 expression after COVID-19 infection might
be part of the up to 2.5-fold increase in T1D incidence.
提供机构：
Dryad
创建时间：
2022-10-06
