Aryl Hydrocarbon Receptor deficiency in intestinal epithelial cells aggravates alcohol-related liver disease

Increasing evidences revealed that intestinal microbiota dysbiosis has been implicated in the progression of ALD, thus we employed sequencing analysis of 16S rRNA to investigate the effect of intestine-specific Ahr disruption to gut microbiota. Ahrfl/fl and AhrIEC mice fed with a control (ISO) and ethanol diet were investigated.