NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>

本事件系基于对另一物种已验证事件的计算推断所得。推断依据PANTHER的同源性映射。概而言之，对于所有参与物理实体（输入、输出及催化剂）均具有映射同源/旁系同源（对于复合物而言，至少75%的组成部分需进行映射）的反应，将其推断至其他物种。此外，对这些事件亦进行高级别事件的推断，以便于更便捷的导航。<p>有关Reactome中事件推断的更多细节及注意事项，请参阅：<a href='/electronic_inference_compara.html' target = 'NEW'>事件推断详情及注意事项。</a>关于PANTHER的详细信息，亦可访问：<a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>