Application of a novel impedance-based freeze-drying Microscopy for formulation development. Formulation solutions for diversifying biopharmaceutical portfolios, 11th July 2019, Manchester, UK

Poster and Podium presentation at Formulation solutions for diversifying biopharmaceutical portfolios; Knowledge Transfer Event (Innovate UK) at Manchester Institution of Biotechnology; 11 July 2019.

Over the past few decades, a number of analytical
instruments have been developed for the characterization of product
formulations intended for Lyophilisation. Freeze-drying microscopy (FDM) is now
used routinely to determine the critical temperature at which the product may
collapse during primary drying (Tc) whereas a combination of differential
thermal analysis (DTA) with electrical impedance analysis has been used to study the critical
temperatures of a sample in a frozen state (i.e. the glass transition, ice
crystallisation and eutectic melting temperatures). In this study, a
combination of impedance spectroscopy with freeze-drying microscopy (Z-FDM, G.
Smith, 2019) has been reported for the first
time.