ESSL_CCCN_plusnegdualedges

Co-cluster correlation network (CCCN) derived from posttranslational modifications (PTMs) from 15 independent tandem mass tag mass spectrometry experiments, each with 6 multiplex samples, from a comparison of 45 lung cancer cell lines, 12 derived from SCLC and 33 from NSCLC, to normal lung tissue, and selected cell lines treated with anti-cancer drugs. This disconnected network includes threshold-filtered Spearman correlations among t-SNE-clustered PTMs (yellow edges are positive correlations; blue, negative). Also shown are negative correlations among different modification types within the same protein.  Node size and color reflects the total of all PTM ratios in the data set (blue is negative; yellow, positive).