Expression profile of microenvironment of morphological structures in breast cancer

The aim of this work is to compare the expression profiles of the microenvironment of various morphological structures of luminal breast cancer obtained by laser microdissection. For this, sections of primary breast carcinoma were stained according to the RNA-preserving protocol, fragments of the stroma around alveolar, trabecular, solid structures and single tumor cells were isolated using a laser capture microdissection, and then RNA-sequencing was performed using Illumina NextSeq500. Our study presents the first analysis of DEGs and activated signaling pathways of the microenvironment of various morphological structures of breast cancer. Gene expression profiles in cells located in the closest microenvironment to the morphological structures of breast cancer