Addition of a GlcNAc on the alpha 1,4 branch by MGAT2

The addition of a GlcNAc on the alpha-1,6 mannose on the alpha-1,4 branch is required for the synthesis of complex N-glycans (Tan et al. 1995). Defects in this gene are associated with Congenital Disorder of Glycosylation type IIa (Tan et al. 1996, Wang et al. 2002).

于α-1,4糖苷链上的α-1,6甘露糖残基添加GlcNAc对于复杂N-聚糖的合成至关重要（Tan等，1995年）。该基因的缺陷与先天性糖基化障碍IIa型（Tan等，1996年，Wang等，2002年）相关。