Developing Thiosemicarbazonato Technetium and Rhenium Radiopharmaceuticals for Nuclear Imaging and Therapy

Nuclear imaging and therapy play a crucial role in diagnosing and treating diseases, particularly cancer, by using radiopharmaceuticals to visualise and target specific areas in the body. This research focuses on technetium, commonly used in medical imaging, and rhenium, which is used for therapy. It explores new methods to link these radioisotopes to biological molecules for targeting disease, such as prostate cancer. This thesis shows that thiosemicarbazone chelators with technetium and rhenium have the potential to create versatile radiopharmaceuticals and could offer a non-invasive approach to monitor disease progression and deliver targeted treatment.