Gene Therapy Omnibus

The Gene Therapy Omnibus (GTO) is a free, specialized resource in the field of gene therapy. It compiles data from global clinical trial registration platforms and the literature, along with pre- and post-therapy transcriptomic data from the GEO and ArrayExpress. This information is meticulously organized, stored, and analyzed to provide valuable insights into gene therapy research. The database contains a total of 6,333 clinical trial records and 3,466 transcriptome profiles. These include 614 altered genes (e.g., p53, VEGFA, NY-ESO-1) and 22 types of gene therapy (e.g. CAR-T, TCR-T, gene transfer, ASO, mRNA vaccine). For each gene therapy product, detailed information is provided, including the altered gene name, structural components, indication, vector, clinical trial phase, and, where available, clinical outcomes and adverse effects.

基因治疗综合数据库（Gene Therapy Omnibus, GTO）是基因治疗领域的免费专业资源。该库整合了来自全球临床试验注册平台、学术文献的数据，以及来自基因表达综合数据库（Gene Expression Omnibus, GEO）与ArrayExpress数据库的治疗前后转录组学数据。所有信息均经过精细化整理、存储与分析，可为基因治疗研究提供极具价值的研究洞察。本数据库共计收录6333条临床试验记录与3466份转录组学图谱，涵盖614个修饰靶基因（如p53、VEGFA、NY-ESO-1）以及22类基因治疗手段，例如嵌合抗原受体T细胞（CAR-T）、T细胞受体修饰T细胞（TCR-T）、基因转移疗法、反义寡核苷酸（Antisense Oligonucleotide, ASO）、mRNA疫苗等。针对每一款基因治疗产品，数据库均提供详细信息，包括修饰靶基因名称、结构组成、适应症、载体类型、临床试验阶段，以及可获取的临床结局与不良反应数据。

搜集汇总

背景与挑战

背景概述

Gene Therapy Omnibus (GTO) 是一个专注于基因治疗领域的免费专业数据库。它整合了来自临床试验注册平台、文献及转录组学数据库的公开数据，总计包含超过6,300项临床试验记录和3,400多个转录组图谱，涵盖614个关键基因和22种疗法类型。该数据库对每种基因治疗产品提供了从基因改造、结构组成到临床试验阶段及结果在内的详细信息。