Promoter architectures associated with TSSes of roundabouts.

Strong sites* are shown in bold font. Those detected in ECs are marked with (+). GATA2 and GATA3, as well as AP-1 subunits (FOS and JUN-family) TFBSes are underlined. The sites do not include polymerase type II peaks whose number correlates trivially with the level of gene expression. We note that in some loci high-affinity sites were shown to be inhibitory while low-affinity sites were shown to activate transcription [108]. This is not the case for ROBO4 as most of its strong TFBSes were activating endothelial sites. However, several weak sites of ROBO4-TSS1 were also of endothelial origin, suggesting both strong and weak TFBSes could be functional in this promoter architecture.