TOXsIgN

The TOXicogenomic sIgNature (TOXsIgN) is a user-friendly and cross-species resource that supports online submission, storage, and retrieval of TOXicogenomic sIgNatures. TOXsIgN aims at complementing existing resources by acting as a distribution hub for the community. One of its unique features is its ability to archive heterogeneous data. TOXsIgN thus allows users to upload lists of genes positively affected and negatively (underexpressed) affected from distinct –omics experiments (e.g., transcriptomics, proteomics, or epigenomics). It also provides users with a working environment containing a powerful search engine as well as bioinformatics/biostatistics modules that enable cross-species and cross-technology signature comparisons or enrichment analyses.毒基因组特征资源（TOXicogenomic sIgNature，缩写TOXsIgN）是一款易用且跨物种的科研资源，支持毒基因组特征的在线提交、存储与检索。TOXsIgN旨在作为科研社区的分发枢纽，补充现有相关资源。其独特特性之一在于能够归档异构数据，因此允许用户上传来自不同组学实验（如转录组学、蛋白质组学或表观基因组学）中受正向调控与负向调控（表达下调）的基因列表。该资源还为用户提供集成了强大搜索引擎与生物信息学/生物统计学模块的工作环境，可实现跨物种、跨技术的特征对比或富集分析。

搜集汇总

背景与挑战

背景概述

TOXsIgN是一个用户友好且跨物种的毒理基因组学特征资源，支持在线提交、存储和检索功能。它作为社区分发中心，能够归档异构数据，允许用户上传来自不同组学实验的基因列表，并提供包含搜索引擎和生物信息学模块的工作环境，以进行跨物种和跨技术的特征比较或富集分析。