Total cell N-glycosylation is altered during differentiation of induced pluripotent stem cells to neural stem cells and is disturbed by trisomy 21 - raw data

To better understand how T21 affects N-glycosylation during neural differentiation, we comprehensively characterized and compared the total N-glycomes of induced pluripotent stem cells (iPSCs) and their neural stem cell (NSC) derivatives. We utilized an isogenic in vitro model of T21 in which both T21 and euploid disomic karyotype (D21) clones were obtained from a single individual with mosaic DS. N-glycomics analysis of whole cell lysates was performed using liquid chromatography coupled with tandem mass spectrometry to determine proposed N-glycan structures. Here we upload the raw data files for the analysis.