SLC35B2,3 transport cytosolic PAPS to Golgi lumen

The human gene SLC35B2 encodes the adenosine 3'-phospho 5'-phosphosulfate transporter 1 (PAPST1) (Ozeran et al. 1996, Kamiyama et al. 2003). In human tissues, PAPST1 is highly expressed in the placenta and pancreas and present at lower levels in the colon and heart. The human gene SLC35B3 encodes a human PAPS transporter gene that is closely related to PAPST1. Called PAPST2, it is predominantly expressed in the colon (Kamiyama et al. 2006). Both proteins can transport PAPS from the cytosol to the Golgi lumen.

人类基因SLC35B2编码腺苷3'-磷酸5'-磷酰硫酸转运蛋白1（PAPST1）（Ozeran等，1996年，Kamiyama等，2003年）。在人类组织中，PAPST1在胎盘和胰腺中高度表达，而在结肠和心脏中的表达水平较低。人类基因SLC35B3编码一种与PAPST1密切相关的PAPS转运蛋白基因，称为PAPST2，其主要在结肠中表达（Kamiyama等，2006年）。这两种蛋白质均能将PAPS从细胞质转运至高尔基体腔。