SNPs associated with ptxA1, prn2/3 and ptxP3.

(a)SNP no corresponds to numbers in row 2 of Supplementary table S4: Annotation of SNPs. More information about the SNP can be found in this table.(b)Subcellular localization was predicted for proteins were no localization was determined experimentally using PSORTb vs 3.0 (http://www.psort.org/psortb/). Cyt: cytoplasm, im: inner membrane, per: periplasm, om: outer membrane, es: extracellular space, uk: unknown, -: not determined.(c)Information of regulation by bvg was retrieved from Cummings et al. [56], Streefland et al. [78] and de Gouw et al. in preparation. Act: bvg-activated, rep: bvg-repressed.(d)Information about domains, active sites and conserved positions was derived from SMART (http://smart.embl-heidelberg.de) and Conserved Domain Database (http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml).