Place-cell representation of volumetric space in rats

Summarised dataset in Matlab compatible files used to analyse and generate figures for:Roddy M. Grieves, Selim Jedidi-Ayoub, Karyna Mishchanchuk, Anyi Liu, Sophie Renaudineau and Kate J. Jeffery (2019) The place-cell representation of volumetric space in ratsIn submission to NatComms, a preprint version is also available on bioRxiv: https://doi.org/10.1101/698175Abstract:Place cells are spatially modulated neurons found in the hippocampus that underlie spatial memory and navigation: how these neurons represent 3D space is crucial for a full understanding of spatial cognition. We wirelessly recorded place cells in rats as they explored a cubic lattice climbing frame which could be aligned or tilted with respect to gravity. Place cells represented the entire volume of the mazes: their activity tended to be aligned with the maze axes, and when it was more difficult for the animals to move vertically the cells represented space less accurately and less stably. These results demonstrate that even surface-dwelling animals represent 3D space and suggests there is a fundamental relationship between environment structure, gravity, movement and spatial memory.All main text and most supplementary figures and analyses can be replicated using this summary dataset in combination with the Matlab code bundle which is also available for download. Matlab .mat files are provided in zipped format (11.15 GB). A readme file with some introductory text is also provided (4 kB).

该数据集为Matlab兼容文件，用于分析及生成图表，以支撑Roddy M. Grieves、Selim Jedidi-Ayoub、Karyna Mishchanchuk、Anyi Liu、Sophie Renaudineau及Kate J. Jeffery等人在2019年的研究成果：《大鼠脑内体积空间中的位置细胞表征》（In submission to NatComms，预印本可在bioRxiv上获取：https://doi.org/10.1101/698175）。摘要如下：位置细胞是海马体中的一种空间调制神经元，其是空间记忆与导航的基础；理解这些神经元如何表征三维空间对于空间认知的全面理解至关重要。本研究通过无线技术记录了大鼠在探索一个可相对于重力进行对齐或倾斜的立方形攀爬框架时位置细胞的活动。位置细胞表征了迷宫的整个体积：其活动往往与迷宫的轴对齐，当动物在垂直方向上移动变得困难时，细胞对空间的表征变得更加不准确且不稳定。这些结果证明了即使是表面居住的动物也能表征三维空间，并暗示了环境结构、重力、运动与空间记忆之间存在根本性的联系。所有主要文本以及大部分补充图表和分析均可通过本摘要数据集与提供的Matlab代码包进行复制。提供的Matlab .mat文件以压缩格式（11.15 GB）提供。此外，还附带了一个包含一些简介文本的readme文件（4 kB）。