Early Developmental Deficits in the CF sheep model

Cystic Fibrosis (CF) is associated with pathology in multiple tissues including the lung, digestive tract and reproductive system. Lung disease is primarily a post-natal event but other organs are affected before birth. Here we use the CF sheep model to investigate the initiation and progression of CF disease through gestation. Overall design: RNA-seq of sheep (ovis aries) tracheal epithelial tissue