DataSheet1_The Role of Biodegradable Magnesium and Its Alloys in Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis Based on Animal Studies.DOCX

Objective: The actual efficacy of magnesium and its alloy in anterior cruciate ligament reconstruction (ACLR) was systematically evaluated to reduce the risk of translation from animal experiments to the clinic.Methods: Databases of PubMed, Ovid-Embase, Web of Science, CNKI, Wanfang, VIP, and CBM were searched for literature in July 2021. Screening of search results, data extraction, and literature quality evaluation were undertaken independently by two reviewers.Results and discussion: Seven articles were selected for the meta-analysis. The results showed that the mechanical properties of the femoral-tendon graft–tibia complex fixed with magnesium and its alloys were comparable to those fixed with titanium and its alloys, and magnesium and its alloys were superior to titanium and its alloys in promoting new bone formation. In addition, the unique biodegradability made magnesium and its alloys an orthopedic implant with significant therapeutic potential. However, whether the degradation rate of magnesium and its alloy can match the rate of bone-tendon integration, and whether the bioconjugation of bone-tendon after degradation can meet the exercise load still needs to be explored in further detail. Simultaneously, it is necessary for future research to improve and standardize experimental design, result measurement, etc., so as to minimize the risk of transforming animal experimental results into clinical practice.

目标：系统性地评估了镁及其合金在前交叉韧带重建（ACLR）中的实际疗效，旨在降低从动物实验向临床转化的风险。方法：于2021年7月，对PubMed、Ovid-Embase、Web of Science、CNKI、万方、VIP和CBM等数据库进行了文献检索。由两位评审员独立进行检索结果的筛选、数据提取和文献质量评估。结果与讨论：共选取七篇文献进行荟萃分析。结果显示，使用镁及其合金固定的股骨-肌腱-胫骨复合体的力学性能与使用钛及其合金固定的相当，且镁及其合金在促进新骨形成方面优于钛及其合金。此外，镁及其合金的独特生物可降解性使其成为一种具有显著治疗潜力的骨科植入物。然而，镁及其合金的降解速率是否能够与骨-肌腱整合的速率相匹配，以及降解后骨-肌腱的生物结合是否能够满足运动负荷，仍需进一步深入研究。同时，未来研究有必要改进和标准化实验设计、结果测量等，以最大限度地降低将动物实验结果转化为临床实践的风险。